We have been performing three lines of research in the field of analytical chemistry.
The first is research by derivative spectrophotometry. Background signals in absorption spectra arising from the turbidity or coexisting solutes in sample solutions are eliminated in their derivative spectra, so that we can obtain quantitative information from suspension samples without separation procedures. Further, as small changes in absorption spectra are intensively enhanced in the derivative spectra, hidden spectral changes are easily detectable in the derivative spectrum. By using the derivative technique, we have been studying drug-protein binding and drug partitioning to liposomes or lipid nanoparticles, and clarifying the effects of endogenous compounds such as fatty acids, inorganic ions or sugars on the interactions between drugs and these biological substances.
The second line of research is multi-nuclear (1H, 13C, 19F, 27Al) magnetic resonance spectroscopic research on the structural elucidation of these drug-biological substance interactions.
The third line of research focuses on the application of a molecularly imprinted polymer to a recognition element of potentiometric immunosensor. In the field of medicine, development of non-invasive methodology for clinical analysis that enables real-time monitoring and/or development of technology that enables real-time monitoring of dynamic changes in a chemical substance which occur in an in vivo minute region are desired. As a novel analytical technology for achieving the goal of these desires, we are developing a needle-type ultra micro potentiometric immunosensor using artificial antibody based on a molecularly imprinted polymer..