On March 11-12, 2025, Kyoto Pharmaceutical University will host the International Symposium 2025, in collaboration with the “Plan for Fostering Next-Generation Cancer Specialists” (Ministry of Education, Culture, Sports, Science and Technology).
The symposium will feature presentations and engaging discussions on the following projects, selected in 2023 under the "KPU Synergetic Research Project" and the "KPU Fund for International Collaborative Research":
- Development of Neurotheranostics Encompassing Early Diagnosis, Disease Modification, and Functional Compensation of Neurodegenerative Diseases
- Elucidating Molecular Chemistry of the Cooperative Mechanism Between Membrane Proteins and Lipids and the Creation of Novel Functional Modulators for Membrane Receptors
- Development of Next-Generation Therapy Combining Adipose-derived Stem Cells with Immune Activators
This year's program will showcase cutting-edge lectures by 11 internationally renowned researchers at the forefront of their fields, whose work aligns with the aforementioned projects. With its state-of-the-art research infrastructure, Kyoto Pharmaceutical University aims to provide a platform for discussing groundbreaking academic insights and strategically promoting network formation for next-generation collaborative research.
This symposium will be co-sponsored by “Plan for Fostering Next-Generation Cancer Specialists” an initiative that aims to foster medical professionals who can respond to modern cancer care needs and facilitate the rapid advancement of the field of cancer treatment. The objective of this plan is to continue to promote the wholistic integration of interdisciplinary knowledge and technology to foster the next generation of highly specialized medical professionals.
■KPU International Symposium 2025
Date: March 11 (Tues) and 12 (Wed), 2025
Venue: A21 Lecture Hall, Aigaku-kan Building, Kyoto Pharmaceutical University
program：
KPU International Symposium
Joint with “Plan for Fostering Next-Generation Cancer Specialists” and “KPU Synergetic Research Project Seminar”March 11(Tue)-12(Wed)
Day1 (March 11)
Towards understanding and modulating biological phenomenon on the membrane
The disruption of receptor tyrosine kinase (RTK)-mediated signaling is closely associated with severe diseases such as cancer. These receptors are known to function by interacting with a variety of lipid molecules within biological membranes. This session will present the latest research uncovering the chemistry of RTKs and their "concert" with lipid molecules. Insights from this session may lead to novel drug discovery strategies targeting RTKs.
10:00-10:30 Takeshi Sato (Kyoto Pharmaceutical University)
Suggestion from the computational chemistry for EGFR and lipids
10:30-11:00 Hiroko Asahina (Kyoto Pharmaceutical University)
Strategy for structural analysis of membrane protein with semi-synthesis
11:00-11:30 Francisco Barrera (University of Tennessee, Knoxville)
Lipid control of receptor tyrosine kinase assembly and function
11:30-12:00 Kazuya Kabayama (Osaka University)
Regulation of dynamics of plasma membrane-associated molecules by glycosylation
Synthesis and application of molecular probe for membrane-related biological system
Dynamic molecular interactions such as lipid-lipid, lipid-protein, and protein-protein interaction in the cell membrane play crucial roles for a variety of fundamental biological processes. Therefore, these interactions have attracted much attention as potential targets for drug discovery. This session will provide synthetic study of artificial phospholipid for investigating lipid-protein interaction, and chemical biological approaches for immune response with the synthetic molecular probes. Furthermore, drug delivery system toward cancer cells based on carbohydrate-protein interactions will also be presented.
13:30-14:00 Takumi Furuta (Kyoto Pharmaceutical University)
Synthetic study of catalytically active head group functionalized phospholipid
14:00-14:30 Yukari Fujimoto (Keio University）
Immunomodulatory functions of cell membrane complex lipids: synthesis and selective activation
14:30-15:00 Xuefei Huang（Michigan State University, Department of Chemistry)
New hyaluronan like polysaccharides with enhanced CD44 affinity for molecular imaging and targeted drug delivery
Topics of translational research in diagnosis and therapy of various diseases using radioligands: From bench to bedside
Combination of diagnosis and therapy using radiopharmaceuticals (radiolabeled ligands): radiotheranostics is attracting attention as a very useful approach for selecting the optimal treatment at the individual patient level (personalized medicine, precision medicine). In this session, we will provide cutting-edge research topics on the status of target molecule discovery, ligand development, and clinical deployment to realize radiotheranostics. We hope that our lecture will be an opportunity for the audience to learn more about radiotheranostics and that it will become a basis for accelerating future transdisciplinary research.
15:30-16:00 Hidekazu Kawashima (Kyoto Pharmaceutical University)
Radiotheranostics of highly malignant tumors: Our approach targeting cancer-associated fibroblasts (CAFs)
16:00-16:30 Koki Hasegawa (Fukushima Medical University)
Innovative nuclear medicine techniques and radiopharmaceuticals: Bridging laboratory development and clinical requirements
16:30-17:00 Michael Decker (University of Würzburg)
Monitoring cardiac diseases by 18F-labebled GPCR ligands: Development of PET-radiotracers based on sartans and CXCR2-ligands
Day２ (March 12)
Cross-disciplinary research aimed at developing Neurotheranostics for the diagnosis and treatment of neurodegenerative diseases
As the global population ages, there is an urgent need to establish comprehensive measures for the early diagnosis and treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, along with their management. The concept of neurotheranostics is evolving; it is no longer just a tool for simultaneous diagnosis and treatment but is being redefined as a technological development that spans from basic research to actual clinical practice in the field of neurodegenerative diseases. This symposium will bring together researchers from various fields, including genetic engineering, pharmacology, and medicine, to explore neurotheranostics. They will introduce and discuss approaches related to diagnosis, treatment, and regenerative medicine. It is anticipated that this collaborative effort across multiple academic disciplines will lead to synergistic research advancements in the development of neurotheranostics.
10:00-10:20 Kazuyuki Takata (Kyoto Pharmaceutical University)
Application of Neurotheranostics in Basic Research of Alzheimer's Disease
10:20-10:40 Masatoshi Inden(Gifu Pharmaceutical University)
Developing and Analyzing Cell Models for Protein Aggregation in Neurodegenerative Diseases.
10:40-11:20 Knut Woltjen (CiRA, Kyoto University)
Precision Genome Editing in Human Induced Pluripotent Stem Cells
11:20-11:00 Wado Akamatsu (Juntendo University)
iPS Cell-Based Disease Modeling and Drug Discovery for Neurological Diseases.
Advancement of cardiac disease therapy and application to new therapies using adipose-derived stem cells
Adipose-derived stem cells (ASCs) have emerged as a promising tool in regenerative medicine, particularly in the context of cardiac disease therapy. This session will elucidate the mechanisms by which ASC-derived bioactive factors modulate cardiac function and facilitate myocardial repair, highlighting recent advances in cell-based therapeutic strategies. We will present findings from our collaborative research with National Taiwan University and introduce results from international clinical studies. By advancing international research collaborations, we aim to accelerate the development of innovative and clinically translatable strategies for cardiac disease treatment.
13:30-14:00 Shinji Kobuchi (Kyoto Pharmaceutical University)
Therapeutic potential of human adipose-derived stem cell-conditioned medium in cardiac disease
14:00-14:30 Wan-Tseng Hsu (National Taiwan University)
Exploring mitochondrial protective strategies in the context of heart failure
14:30-15:00 Shin-Yi Lin (National Taiwan University)
Clinical utilization of direct oral anticoagulant concentration monitoring
Media contacts:
Kyoto Pharmaceutical University
Office for Planning & Public Relations
https://www.kyoto-phu.ac.jp/english/contact/